Histological Spectrum of Large Intestinal Lesions with Clinicopathological Correlation
Published: November 1, 2015 | DOI: https://doi.org/10.7860/JCDR/2015/.6842
Ritesh Sulegaon, Smita Shete, Dinesh Kulkarni
1. Assistant Professor, Department of Pathology, Bidar Institute of Medical Sciences, Bidar, India.
2. Assistant Professor, Department of Pathology, Dr. V.M. Govt. Medical College, Solapur, India.
3. Associate Professor, Department of Pathology, Bidar Institute of Medical Sciences, Bidar, India.
Correspondence
Dr. Ritesh Sulegaon,
Swetha” H.No. 19-1-218/A, Mahadev Colony, Shivnagar South, Bidar-585401, Karnataka, India.
E-mail: docritz@gmail.com
Introduction: Large intestine is affected by various types of lesions, both non-neoplastic and neoplastic. Due to vague symptoms, the clinical diagnosis is usually delayed. A battery of laboratory tests including biopsy is essential to arrive at a specific diagnosis for appropriate management.
Materials and Methods: This five years study was done during the period of 2005 to 2010 in a tertiary care centre which included 124 biopsies and resected specimens of large intestine and 64 from Anal canal. All tissues were fixed in formalin, stained with H&E and special stains like Periodic Acid Schiff (PAS), Reticulin, Zeihl Neelsen (ZN) along with Immunohistochemistry (IHC) were done as and when required.
Results: Out of the 124 cases of large intestine 38 were non-neoplastic, 77 were neoplastic and 9 were inadequate biopsies. Sixty four cases from Anal canal included 55 non-neoplastic and 9 neoplastic lesions. The non-neoplastic conditions included congenital anomalies, infective and ischaemic lesions while neoplastic included benign and malignant lesions. Most of the cases presented with symptoms like abdominal pain, vomiting and constipation.
Conclusion: We observed that neoplastic lesions were more common in large intestine while non-neoplastic lesions were frequently seen in Anal canal. Present study emphasizes the need for early histopathological diagnosis for appropriate treatment.
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